Allostery in Niemann–Pick C1 (NPC1)

Large-scale NPC1 domain motions associated with cholesterol occupancy of the sterol-sensing region.

Simulations show how the conformations of NPC1 luminal domains respond to cholesterol occupancy at a membrane-binding site.

Large-scale NPC1 domain motions associated with cholesterol occupancy of the sterol-sensing region.

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Reference

Dubey V, Bozorg B, Wüstner D, Khandelia H. Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain. PLoS Computational Biology. 2020;16(10):e1007554. DOI: 10.1371/journal.pcbi.1007554