Annexin-induced membrane curvature

Annexin organization on an anionic membrane and the associated membrane-curvature response.

Human Annexin A4 binds to an anionic membrane and participates in membrane-remodelling processes associated with membrane repair.

Annexin A4 organization on an anionic membrane and the associated membrane deformation and curvature response.

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References

Florentsen CD, Kamp-Sonne A, Moreno-Pescador G, Pezeshkian W, Hakami Zanjani AA, Khandelia H, Nylandsted J, Bendix PM. Annexin A4 trimers are recruited by high membrane curvatures in giant plasma membrane vesicles. Soft Matter. 2021;17(2):308–318. DOI: 10.1039/d0sm00241k

Hakami Zanjani AA, Mularski A, Heitmann ASB, Dias C, Møller ME, Maeda K, Nylandsted J, Simonsen AC, Khandelia H. Engineering a membrane-binding protein to trimerize and induce high membrane curvature. Biophysical Journal. 2023;122(14):3008–3017. DOI: 10.1016/j.bpj.2023.04.002